News and Events


Cushman Study Shows Benefits of Early Anticlotting Therapy in Moderate COVID-19
Mary Cushman

Results from an international grassroots-funded multi-center clinical trial co-led by Mary Cushman, M.D., M.Sc., professor in the Division of Hematology/Oncology, show that giving a full dose of heparin early to moderately ill hospitalized COVID-19 patients could reduce the risk of severe disease and death. The RAPID Trial was designed to detect differences in the primary outcomes of moderately ill hospitalized COVID-19 patients, such as ICU admission, mechanical ventilation, or death. Participants were randomized to receive either a therapeutic full dose or prophylactic low dose of heparin – a blood thinner given regularly at low dose to hospitalized patients to stop clots from forming and reduce inflammation. Co-PIs with Cushman are Michelle Sholzberg, M.D.C.M., M.Sc., and Peter Jüni, M.D., of St. Michael’s Hospital of Unity Health Toronto and the University of Toronto. Read more.

 

Ninth Biennial Stem Cell Conference a Success
Daniel WeissUVM hosted the 9th biennial Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases Conference July 12-15. Traditionally held at UVM since 2005, this year’s virtual conference had nearly 200 participants, the highest number ever, and remains the leading conference in these rapidly evolving areas. Daniel Weiss, M.D., Ph.D., professor in the Division of Pulmonary Disease and Critical Care Medicine, is emeritus conference chair. He co-developed the first conference and served as co-chair of several past conferences. This year's event had attendance from researchers from five continents and 13 countries. Participants, which include both top researchers and trainees, discuss recent study findings, explore opportunities for new collaborations, and identify the most important needs and priorities for future programs. Read more.

 

 

Pierce Plays Key Role in Vaccine Education for New American Communities

Kristen PierceKristen Pierce, M.D., professor in the Division of Infectious Disease, has been playing a lead role in COVID-19 vaccination outreach to New American communities in Vermont. In collaboration with VT LEND and community leaders from several location organizations including UVM Health Network’s Government and Community Relations Office, U.S. Committee for Refugees and Immigrants-Vermont and Association of Africans Living in Vermont, she has been hosting virtual education sessions since the vaccine became available. The goal is to share the reasons why it’s important to get the vaccine and answer questions to encourage community members to get vaccinated. There were a total of 17 COVID-19 vaccine education sessions delivered via Zoom between December 2020 and March 2021 to the following communities/languages: Nepalese-Bhutanese; Congolese (three separate sessions – one each for Swahili, French, and Lingala languages); Somali (three separate sessions – one each for Somali, Maay Maay, and Kirundi languages); Arabic-speaking; Nepalese elders; Karen Burmese; and Vietnamese. Vaccine information flyers translated into all these languages have been distributed to communities.


Awards and Recognition

National Service and Leadership Roles

Harold DauermanHarold Dauerman, M.D., professor in the Division of Cardiovascular Medicine, has three new national roles:

  • Member of the National Executive Committee for the TAVR EXPAND trial—A comparison of medical therapy versus early TAVR in patients with moderate aortic stenosis. Sponsor: Medtronic
  • Member of the Scientific Output Committee, Society of Cardiac Angiography and Interventions
  • Member of the Scientific Publications Committee Peer Review Task Force, American College Cardiology Scientific Publications Committee



Jason Botten, Ph.D., professor in the Division of Immunobiology, was an ad hoc reviewer for the National Institutes of Health Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section (DDR).

Steven Lidofsky, M.D., Ph.D., professor in the Division of Gastroenterology and Hepatology, has been appointed vice chair for the American Association for the Study of Liver Diseases Public Policy Committee (January 2021-December 2021)

2021 Department of Medicine Faculty Awards

Distinguished Clinician Award
  • Eric Ganguly, M.D., professor in the Division of Gastroenterology and Hepatology
  • Kim Dittus, M.D., Ph.D., associate professor in the Division of Hematology/Oncology
Distinguished Mentor Award
  • Philip Ades, M.D., professor in the Division of Cardiovascular Medicine
Quality Scholarship Award
  • Preetika Muthukrishnan, M.B.B.S., M.Sc., assistant professor in the Division of Hospital Medicine


2021 Resident Graduation Celebration Awards

FACULTY AWARDS

E.L. Amidon, M.D. Award
  • Outstanding Teacher of the Year Subspecialty Medicine
    Sheela Reddy, M.D., assistant professor in the Division of Gastroenterology and Hepatology
Mark A. Levine, M.D. Award
    Outstanding Teacher of the Year General Internal Medicine
    Caleb Burr, M.D., assistant professor in the Division of Hospital Medicine


RESIDENT AWARDS

The Harriet P. Dustan, M.D. Award

In recognition of acquisition of new knowledge through research performed during residency

  • Sundas Khan, M.D.
The Frank L. Babbott, M.D. Memorial Award

For idealism and integrity, dedication to patient care, commitment to the educational mission of the Department of Medicine

  • Kenyon Bolton, M.D.
Richard E. Bouchard, M.D. Excellence in Primary Care Award

For providing high quality comprehensive care, for dedication as an educator of patients, medical learners and support staff, for sincere and genuine concern for patients

  • Kenyon Bolton, M.D.



Faculty and Staff News

Recent Promotions
  • Jason Botten, Ph.D., promoted to professor of medicine with tenure in the Division of Immunobiology
  • Chris Holmes, M.D., Ph.D., promoted to professor of medicine with tenure in the Division of Hematology/Oncology
  • C. Matthew Kinsey, M.D., M.P.H., promoted to associate professor of medicine with tenure in the Division of Pulmonary Disease and Critical Care Medicine
  • Neil Zakai, M.D., M.Sc., promoted to professor of medicine with tenure in the Division of Hematology/Oncology

News and Notes

Diego Adrianzen Herrera, M.D., assistant professor in the Division of Hematology/Oncology, was accepted to the American Society of Hematology’s Clinical Research Training Institute (CRTI) and the CRTI Oversight Subcommittee.

Sean Bullis, M.D., completed UVM’s Infectious Disease Fellowship program in June and joined the Division of Infectious Disease as a physician and assistant professor in July.

Jean Dejace, M.D., assistant professor in the Division of Infectious Disease, has been appointed fellowship director for the UVM Infectious Disease Fellowship program.

Josh Farkas, M.D., associate professor in the Division of Pulmonary Disease and Critical Care Medicine, received the Gold Foundation’s Champions in Humanism Award after being nominated by the Larner College of Medicine’s Gold Humanism Honor Society, in partnership with the UVM Medical Center. The award pays tribute to healthcare professionals for the humanistic care they have displayed through the COVID-19 pandemic. Awardees were recognized on June 10 at the Gold Foundation’s 2021 Annual Gala.

Victoria Hart, Ph.D., assistant professor of medicine for the public health program, received the the Larner College of Medicine Teaching Academy’s 2021 Curriculum Development and Scholarship Award for "Development of asynchronous online modules to support medical student education in public health science.”


Education News


New Residents and Fellows

New Residents
Categorical
Faiz (Jaspar) Abu-Jaber, M.D., Tufts University School of MedicineJordan Morrison-Nozik, D.O., University of New England College of Osteopathic Medicine
Robin Alsher, M.D., Pennsylvania State University College of MedicineAhmed Raza, M.D., Allama Iqbal Medical College 
Daniel Bailey, M.D., Jacobs School of Medicine and Biomedical Sciences, University at BuffaloChastidy Roldan, M.D., State University of New York Downstate Medical Center College of Medicine
Akshee Batra, M.D., Maulana Azad Medical CollegeMassoud Saleki, M.D., University of Washington School of Medicine
Dominique Billingslea, M.D., University of Washington School of MedicineSienna Searles, M.D., UVM Larner College of Medicine
Charlie Forsythe, M.D., University of Washington School of MedicineDeepak Sharma, M.D., Eastern Virginia Medical School of the Medical College of Hampton Roads
Kelsey Maguire, D.O., University of New England College of Osteopathic MedicineSudershan (Shawn) Srinivasan, M.D., Case Western Reserve University School of Medicine
Kristine McLaughlin, M.D., University of Minnesota Medical School
Preliminary
Ryan Beal, D.O., Campbell University Jerry M. Wallace School of Osteopathic MedicineZachary Zimmer, M.D., Jacobs School of Medicine and Biomedical Sciences, University at Buffalo
Karl Heward, M.D., University of Utah School of MedicineCheyenne Hornback, M.D., University of Oklahoma College of Medicine
Samae Scott, M.D., Albany Medical CollegeJoy Lowry, M.D., UVM Larner College of Medicine
Muhannad Seyam, M.D., Semmelweis University Faculty of Medicine
Preliminary Anesthesia shared with Surgery
Javier Blanco, M.D., University of Pittsburgh School of Medicine 
Marc Hammond, M.D., UVM Larner College of Medicine
 
Nicole (Nikki) Kosmider, D.O., Western University of Health Sciences College of Osteopathic Medicine of the Pacific 
Chief Medical Residents
Benjamin Depo, M.D., State University of New York Upstate
Mathew Gervais, M.D., Pennsylvania State University
Kevin Qin, M.D., The University of Toledo
Dermatology Chief Residents
Daniel Bax, M.D., University of Buffalo
Dustin Taylor, M.D., University of Texas
Carli Whittington, M.D., University of Louisville
Dermatology Residents
Nadeem Marghoob, D.O., New York Institute of Technology College of Osteopathic Medicine
Hannah Porter, M.D., University of Pittsburgh
New Fellows

Cardiology

Jan Denkmann, M.D.
Nicole Habel, M.D.
Carrie Mahurin, M.D.
Krina Patel, M.D.
Newton Phuong, M.D.
Tyler Wark, M.D.
Joshua Zimmer, M.D

Hematology/Oncology
David Alejos, M.D.
Rohit Singh, M.D.
Dermatology
Noman Javed, M.D.
Rechelle Tull, M.D.		Infectious Disease
Peter Hyson, M.D.
Endocrinology
Samantha Steinmetz-Wood, M.D.
Pulmonary
Shawn Wayne, M.D.
Joseph Watson, M.D.
Gastroenterology

Edwin Goncharuk, D.O.
Takahiro Nakamura, M.D.

Rheumatology
Dawid Czarny, M.D.

 

Research and Grants

Kathryn HuggettKathryn Huggett, Ph.D., professor in the Division of Pulmonary Disease and Critical Care Medicine and director of the Teaching Academy, is principal investigator for a research study that began in July of 2021 titled “A Phenomenographic Study of the Experiences and Perceptions of Medical School Faculty Who Transformed their Teaching from Lectures to Active Learning.” The project includes three collaborators at the University of New Mexico School of Medicine and McGovern Medical School, part of UTHealth | The University of Texas Health Science Center at Houston.





Mary Cushman, M.D., M.Sc., professor in the Division of Hematology/Oncology, has reports on two clinical trials related to COVID-19. “A multiplatform consortium trial of moderately ill COVID patients hospitalized on the ward showed benefit of full compared to standard of care heparin in reducing organ support-free days or death,” she says. The manuscript was accepted to New England Journal of Medicine. The multiplatform trial for ICU patients making the same comparison was also accepted to New England Journal of Medicine and the treatment was futile in that population.

Steven Lidofsky, M.D., Ph.D., professor in the Division of Gastroenterology and Hepatology, is principal investigator at UVM Medical Center for a multicenter Phase 2 randomized controlled trial for the study of the JNK inhibitor CC-90001 in nonalcoholic fatty liver disease with advanced hepatic fibrosis (2021-2024, sponsor Celgene)

New Grants

Diego Adrianzen Herrera, M.D., assistant professor in the Division of Hematology/Oncology, is principal investigator for a $12,534 grant from the Northern New England Clinical Oncology Society titled “Identifying factors associated with cardiovascular disease in myelodysplastic syndromes: An analysis of the seer-medicare database.”

Jason Botten, Ph.D., professor in the Division of Immunobiology, received a $600,000 National Institutes of Health Small Business Technology Transfer grant to develop broad spectrum antivirals for treatment of multiple families of RNA viruses. He also received a $357,000 corporate award to test antiviral molecules for prophylactic and therapeutic efficacy in SARS-CoV-2 animal models.

David Kaminsky, M.D., professor in the Division of Pulmonary Disease and Critical Care Medicine, received a grant from the Northern New England Clinical and Translational Research Network for a study titled “Feasibility of Home Monitoring in Patients with COPD Exposed to Wood Smoke.”

Hibba Rehman, M.D., assistant professor in the Division of Hematology/Oncology, is principal investigator for a $10,286 grant from the Northern New England Clinical Oncology Society titled “Prevention of Sarcopenia in advanced stage NSCLC patients, undergoing first line treatment with chemotherapy/chemoimmunotherapy through a structured, virtual exercise program. A pilot study.”

Daniel Weiss, M.D., Ph.D., professor in the Division of Pulmonary Disease and Critical Care Medicine, recently received three grants:

  • A $460,000 grant from United Therapeutics for “Modeling Pulmonary Hypertension Drug Mechanisms of Actions in Pulmonary Vascular Smooth Cells: Correlation of in silico and in vitro studies.”
  • A $275,000 grant for “Ex vivo bioengineering of functional biomimetic airways for treatment of neonatal and pediatric respiratory conditions.”
  • A $200,000 American Lung Association Research Grant for “Mechanisms of SARS-CoV-2 Pathogenesis of Type 2 Alveolar Epithelial Cells.”

The follow three teams received UHC funds for research projects in fiscal year 2022:

  • Elie Donath, M.D., assistant professor in the Division of Hospital Medicine, Yao Li, M.D., assistant professor in the Division of Hospital Medicine, and Nicholas Cheney, Ph.D., assistant professor of computer science, for “An AI-based Clinical Text Classification Paradigm for Chest Pain.”
  • Elly Riser, M.D., assistant professor in the Division of Hospital Medicine and Halle Sobel, M.D., assistant professor in the Division of General Internal Medicine, “Developing an Addiction Medicine Elective at the Larner College of Medicine.”
  • Elizabeth Wahlberg, M.D., assistant professor in the Division of General Internal Medicine and Emily Hadley Strout, M.D., assistant professor in the Division of General Internal Medicine, for “Integration of Mentorship and At-The-Elbow Electronic Medical Record Support into a Panel Management Curriculum for Internal Medicine Residents.”

 

In the Media

Mary Cushman, M.D. M.Sc., professor in the Division of Hematology/Oncology, was quoted for a story in The Globe and Mail titled “Scientists grapple with mystery of COVID-19 vaccine-related blood clots.” Read the story published on May 13, 2021.

Timothy Lahey, M.D., M.M.Sc., professor in the Division of Infectious Disease, was quoted in an Associated Press story titled “New England’s success against COVID-19 could be a model,” published on June 5, 2021. Read the article.

Vitor Mori, Ph.D., a postdoctoral fellow in the Department of Medicine and Damon Runyon Cancer Research Foundation-funded Quantitative Biology Fellow, was highlighted in the Damon Runyon News regarding his efforts to help address the COVID-19 crisis in his home city of Sao Paulo, Brazil. Read the article.

 

Publications and Presentations

Publications

Division of Medicine Quality Program

Houston E, Kennedy AG, O'Malley D, Rabinowitz T, Rose G, Boyd J. Telemedicine in Neurology: A scoping review of key outcomes in movement disorders. Telemed J E Health. 2021 Jun 8. doi: 10.1089/tmj.2021.0117. PMID: 34101518

Division of Cardiovascular Medicine

Kusomoto F, Bittl J, Creager MA, Dauerman HL et al. High Quality Peer Review for Clinical and Translational Research: A Task Force of the ACC Scientific Publishing Committee. Journal of the American College of Cardiology 2021. In press

Kirtane AJ, Stoler R, Feldman R, Neumann FJ, Boutis L, Tahirkheli N, Toelg R, Othman I, Stein B, Choi JW, Windecker S, Yeh RW, Dauerman HL, Price MJ, Underwood P, Allocco D, Meredith I, Kereiakes DJ. Primary Results of the EVOLVE Short DAPT Study: Evaluation of 3-Month Dual Antiplatelet Therapy in High Bleeding Risk Patients Treated With a Bioabsorbable Polymer-Coated Everolimus-Eluting Stent. Circ Cardiovasc Interv. 2021 Mar;14(3):e010144

Denkmann JH, Malenka D, Ramkumar N, Ross C, Young MN, Vasaiwal S, Flynn, Dauerman HL. Decade Long Temporal Trends in Revascularization for Patients with Diabetes Mellitus: A Report from the Northern New England Cardiovascular Disease Study Group. The American Journal of Cardiology, 2021. In press

Dauerman HL, Ibanez BJ. The Edge of Time in Acute Myocardial Infarction. J Am Coll Cardiol 2021; 77: 1871–1874

Kadavath SM, Terrien EF, Ittleman FP, Lahoud R, Phuong NP, Dauerman HL, Rescue of Threatened Coronary Obstruction Due to Sinus Sequestration: Valve-in-Valve Transcatheter Aortic Valve Replacement. JACC: Cardiovascular Interventions, 2021:doi.org/10.1016/j.jcin.2021.02.020

Phuong NS, Solomon RJ, Lewinter MM, Lahoud R, Dauerman HL. The Incidence and Predictors of Renin-Angiotensin System Inhibition after TAVR. J Inv Cardiology. In press, 2021

Dauerman HL. The Unbearable Thrombus of COVID 19. J Am Coll Cardiol, 2020; 76: 1177-1180

Division of Dermatology

Ross ADJ, Bombardier N, Schuessler DC, Morley K. Float like a butterfly, sting like one too. Pediatr Dermatol. Published online May 31, 2021

Division of Endocrinology, Diabetes and Metabolism

Gilbert MP, Shah A. A Case of Euglycemic Diabetic Ketoacidosis after Initiation of Ketogenic Diet in a Patient with Type 2 Diabetes on a Sodium-Glucose Co-transporter-2 (SGLT2) Inhibitor. Diabetes Case Studies, 2nd Edition

Barrett K, Sheahan K, Gilbert MP. Onset of Autoimmune Diabetes during Pregnancy. Diabetes Case Studies, 2nd Edition

Gilbert MP, DeVoe SG, Kennedy AG, Ogelby M, Consigli AB, Zimakas PJ, Repp A, Robinson KJ. Improving the Quality of Health Care Transitions for Young Adults at an Adult Endocrinology Clinic. American Diabetes Association Virtual 81st Scientific Session, June 25/29, 2021. Diabetes 2021; 70 Supplement (1): 852-P. AY 20-21

Sheahan KH, Kennedy AG, Tompkins BJ, Repp AB, Gilbert MP. The impact of a nursing strike on glycemic control in hospitalized patients with diabetes. Cureus. 13(6):e16020. doi:10.7759/cureus.16020

Division of Gastroenterology and Hepatology

Rodriguez N, Kennedy AG, Tompkins BJ, VanOpdorp J, Heffley J, Ganguly E. Quality improvement opportunities exist for helicobacter pylori treatment and confirmatory testing. Clin Res Hepatol Gastroenterol. 2021 Jun 1;45(5):101720. doi: 10.1016/j.clinre.2021.101720. PMID: 34087425

Division of General Internal Medicine

Ramos-Nino ME, MacLean CD, Littenberg B. Association between prevalence of obstructive lung disease and obesity: results from the Vermont Diabetes Information System. Asthma Research and Practice 2021; 7:6. https://doi.org/10.1186/s40733-021-00073-1

Colantonio L, Reynolds R, Merriman T, Gaffo A, Singh J, Plante TB, Soliman E, Curtis J, Bridges S, Howard G, Safford M, Saag K, Muntner P, Irvin M. Higher serum urate levels are associated with an increased risk for sudden cardiac death in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Journal of Rheumatology. 2021. In press

Nicoli CD, Carson AP, Plante TB, Long DL, McClure LA, Schulte J, Cushman M. Pro-Neurotensin/Neuromedin N and Risk of Incident Metabolic Syndrome and Diabetes Mellitus in the REGARDS Cohort. J Clin Endocrinol Metab. 2021. In press

Harder VS, Varni SE, Murray KA, Plante TB, Villanti AC, Wolfson DL, Maruti S, Fairfield KM. Prescription Opioid Policies and Associations with Opioid Overdose and Related Adverse Effects. International Journal of Drug Policy. 2021. In press

Munger JA, Koh I, Howard G, Howard V, Plante TB, Wilkinson K, Cushman M, Zakai NA. Television viewing, physical activity and venous thromboembolism risk: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study. J Thromb Haemost. 2021 Jun 2. doi: 10.1111/jth.15408. Epub ahead of print. PMID: 34077616

Prasanna A, Miller HN, Wu Y, Peeler A, Ogungbe O, Plante TB, Juraschek SP. Recruitment of Black adults into cardiovascular disease trials. J Am Heart Assoc. 2021. In press

Riser E, Holterman LA, Maruti S, Brooklyn JR, Devoe SG, Tompkins BJ, Drouin J and Sobel HG. Integrating Addiction Medicine into Undergraduate Medical Education: The Time is Now. Substance Abuse, 1-8, 2021 Apr 06

Oleng NA., Sobel HG, Kwolek D. Cervical Cancer and Human Papillomavirus: Prevention and Screening. Eds. Tilstra SA, Kwolek D, Mitchell JL, Dolan BM. Carson MP. Sex-and Gender-Based Women's Health. Springer, Cham. https://doi.org/10.1007/978-3-030-50695-7_14

Twist KE, Sobel HG. (2020) Urinary Incontinence. Eds. Tilstra SA, Kwolek D, Mitchell JL, Dolan BM. Carson MP. Sex- and Gender-Based Women's Health. Springer, Cham. https://doi.org/10.1007/978-3-030-50695-7_23

Crocker AM, Kessler R, van Eeghen C, et al. Integrating Behavioral Health and Primary Care (IBH-PC) to improve patient-centered outcomes in adults with multiple chronic medical and behavioral health conditions: study protocol for a pragmatic cluster-randomized control trial. Trials. 2021; 22, 200. https://doi.org/10.1186/s13063-021-05133-8

Division of Hematology/Oncology

Chen C, Xun P, Unverzagt F, McClure LA, Irvin MR, Judd S, Cushman M, He K. Serum magnesium concentration and incident cognitive impairment: the Reasons for Geographic and Racial Differences in Stroke study. In Press, Eur J Nutr. 2021 Apr;60(3):1511-1520. doi: 10.1007/s00394-020-02353-7. PMID: 32737612

Oni E, Ogunmoroti O, Allen N, A-Mallah MH, Blankstein R, Martin SS, Zeb I, Cushman M, Joshi PH, Budoff MJ, Blaha MJ, Blumenthal RS, Veledar E, Nasir K. Life’s Simple 7 and Non-Alcoholic Fatty Liver Disease: The Multi-Ethnic Study of Atherosclerosis. Am J Med. 2021 Apr;134(4):519-525. doi: 10.1016/j.amjmed.2020.09.023. PMID: 33285128

Talasaz AH, Sadeghipour P, Kakavand H, Aghakouchakzadeh M, Kordzadeh-Kermani E, Van Tassell BW, Gheymati A, Ariannejad H, Hosseini SH, Jamalkhani S, Sholzberg M, Monreal M, Jimenez D, Piazza G, Parikh SA, Kirtane AJ, Eikelboom JW, Connors JM, Hunt BJ, Konstantinides SV, Cushman M, Weitz JI, Stone GW, Krumholz HM, Lip GYH, Goldhaber SZ, Bikdeli B. Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 Apr;77(15):1903-1921. doi: 10.1016/j.jacc.2021.02.035. PMID: 33741176

Yi SY, Steffen LM, Lutsey PL, Cushman M, Folsom AR. Contrasting Associations of Prudent and Western Dietary Patterns with Risk of Developing Venous Thromboembolism. Am J Med. 2021 Jun;134(6):763-768.e3. doi: 10.1016/j.amjmed.2021.01.016. PMID: 33609530

Graff M, Justice AE, Young KL, Cushman M, Loos R, Ng MCY, North KE. Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry. Am J Hum Genet 2021 Apr 1;108(4):564-582. doi: 10.1016/j.ajhg.2021.02.011. PMID: 33713608

Carson AP, Long DL, Cherrington AL, Dutton GR, Howard VJ, Brown TM, Howard G, Safford MM, Cushman M. Sex differences in factors contributing to the racial disparity in diabetes risk. Am J Prev Med. 2021 Apr;60(4):e169-e177. doi: 10.1016/j.amepre.2020.09.016. PMID: 33279367

Dibaba DT, Cheng C, Liping L, Bidulescu A, Fly AD, Xun P, Judd SE, Cushman M, He K. Magnesium intake is inversely associated with risk of metabolic syndrome in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort study. Clin Nutr. 2021 Apr;40(4):2337-2342. doi: 10.1016/j.clnu.2020.10.024. PMID: 33129598

Thibord F, Song, Pattee J, Rodriguez B, Chen MH, O’Donnell CJ, Kleber ME, Delgado GE, Guo X, Yao J, Taylor KD, Ozel AB, Brody JA, McKnight B, Gyorgy B, Simonsik E, Leonard HL, Carrasquilla GD, Guindo-Martinez M, Silveira A, Temprano-Sagrera G, Yanek LR, Becker DM, Mathias RA, Becker LC, Raffield LM, Kilpelainen TO, Grarup N, Pedersen O, Hansen T, Linneberg A, Hamsten A, Watkins H, Sabater-Lleal M, Nalls MA, Tregouet DA, Morange PE, Psaty BM, Tracy RP, Smith NL, Desch KC, Cushman M, Rotter JI, de Vries PS, Pankratz ND, Folsom AR, Morrison AC, Marz W, Tang W, Johnson AD. FGL1 as a modulator of plasma D-dimer levels: Exome-wide marker analysis of plasma tPA, PAI-1, and D-dimer. J Thromb Haemost. 2021 Apr 20. doi: 10.1111/jth.15345. PMID: 33876560

Harrington L, Ehlert AN, Thacker EL, Jenny NS, Lopez O, Cushman M, Fitzpatrick A, Mukamal KJ, Jensen MK. Hemostatic factor levels and cognitive decline in older adults: the Cardiovascular Health Study. J Thromb Haemost. 2021 May; 19(5):1219-1227. doi: 10.1111/jth.15300. PMID: 33725412

Hu Y, Stilp AM, McHugh CP, Rao S, Jai D, Zheng X, Lane J, Méric de Bellefon S, Raffield LM, Chen MH, Yanek LR, Wheeler M, Yao Y, Ren C, Broome J, Moon JY, de Vries PS, Hobbs BD, Sun Q, Surendran P, Brody JA, Blackwell TW, Choquet H, Ryan K, Duggirala R, Heard-Costa N, Wang Z, Chami N, Preuss MH, Min N, Ekunwe L, Lange LA, Cushman M, Faraday N, Curran JE, Almasy L, Kundu K, Smith AV, Gabriel S, Rotter JI, Fornage M, Lloyd-Jones DM, Vasan RS, Smith NL, North KE, Boerwinkle E, Becker LC, Lewis JP, Abecasis GR, Hou L, O'Connell JR, Morrison AC, Beaty TH, Kaplan R, Correa A, Blangero J, Jorgenson E, Psaty BM, Kooperberg C, Walton RT, Kleinstiver BP, Tang H, Loos RJF, Soranzo N, Butterworth AS, Nickerson D, Rich SS, Mitchell BD, Johnson AD, Auer PL, Li Y, Mathias RA, Lettre G, Pankratz N, Laurie CC, Laurie CA, Bauer DE, Conomos MP, Reiner AP. NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. Whole genome sequencing association analysis of quantitative red blood cell phenotypes: the NHLBI TOPMed program. Am J Hum Genet. 2021 May 6;108(5):874-893. doi: 10.1016/j.ajhg.2021.04.003. PMID: 33887194

Tolaney SM, Kalinsky K, Kaklamani VG, D’Adamo DR, Aktan G, Tsai ML, O’Regan RM, Kaufman PA, Wilks ST, Andreopoulou E, Patt DA, Yuan Y, Wang G, Savulsky C, Xing D, Kleynerman E, Karantza V, Diab S. Eribulin Plus Pembrolizumab in Patients with Metastatic Triple-Negative Breast Cancer (ENHANCE 1): A Phaste Ib/II Study. Clin Cancer Res. 2021 Jun 1;27(11):3061-3068. doi: 10.1158/1078-0432.CCR-20-4726. PMID: 33727258

Kazmi S, Chatterjee D, Raju D, Hauser R, Kaufman PA. Correction to: Overall survival analysis in patients with metastatic breast cancer and liver or lung metastases treated with eribulin, gemcitabine, or capecitabine. Breast Cancer Res Treat. 2021 Jun;187(2):603. doi: 10.1007/s10549-021-06223-6. PMID: 33907908

Wood ME, Liu H, Storrick E, Zahrieh D, Le-Petross HC, Jung SH, Zekan P, Kemeny MM, Charlamb JR, Wang LX, Unzeitig GW, Johnson CS, Garber JE, Marshall JR, Bedrosian I. The influence of vitamin D on mammographic density: results from CALGB 70806 (Alliance) a randomized clinical trial. Cancer Prev Res (Phila). 2021 Apr 13;canprevres.0581.2020. doi: 10.1158/1940-6207.CAPR-20-0581. PMID: 33849913

Ahern TP, Sprague BL, Farina NH, Tsai E, Cuke M, Kontos D, Wood ME. Lifestyle, Behavioral, and Dietary Risk Factors in Relation to Mammographic Breast Density in Women at High Risk for Breast Cancer. Cancer Epidemiol Biomarkers Prev. 2021 May;30(5):936-944. doi: 10.1158/1055-9965.EPI-20-1567. PMID: 33619019

Omran SS, Hartman A, Zakai NA, Navi BB. Thrombophilia Testing After Ischemic Stroke: Why, When, and What? Stroke. 2021 May;52(5):1874-1884. doi: 10.1161/STROKEAHA.120.032360. PMID: 33874743

MacLehose RF, Zakai NA, Walker RF, Alonso A, Adams T, Lutsey PL. Impact of oral anticoagulant choice for the secondary prevention of venous thromboembolism on the risk of inpatient bleeding. Res Pract Thromb Haemost. 2021 May 4;5(4):e12514. doi: 10.1002/rth2.12514. PMID: 33977213

Short SA, Gupta S, Brenner SK, Hayek SS, Srivastava A, Shaefi S, Singh H, Wu B, Bagchi A, Al-Samkari H, Dy R, Wilkinson K, Zakai NA, Leaf DE, STOP-COVID Investigators d-dimer and Death in Critically Ill Patients With Coronavirus Disease 2019. Crit Care Med. 2021 May 1;49(5):e500-e511. doi: 10.1097/CCM.0000000000004917. PMID: 33591017

 

Wiercioch W, Nieuwlaat R, Dahm P, Iorio A, Mustafa RA, Neumann I, Rochwerg B, Manja V, Alonso-Coello P, Ortel TL, Santesso N, Vesely SK, Akl EA, Schunemann HJ, Bates SM, Cuker A, Lim W, Monagle P, Kunkle R, Witt DM, Kahn SR, McLintock C, Rezende SM, Zakai NA, ASH VTE Panels Working Group. Development and application of health outcome descriptors facilitated decision-making in the production of practice guidelines. J Clin Epidemiol. 2021 May 13;S0895-4356(21)00139-6. doi: 10.1016/j.jclinepi.2021.04.016 PMID: 33992716

Stanislawski MA, Lange LA, Raffield LM, Zakai NA, Meyer M, Ferrier K, Szeto MD, Leavitt C, Shortt JA, Thornton TA, Tracy RP, Auer PL, Reiner AP, Lange EM, Olson NC. Soluble CD14 Levels in the Jackson Heart Study: Associations with Cardiovascular Disease Risk and Genetic Variants. Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e378. doi:10.1161/ATVBAHA.121.316035. PMID: 33910371

Division of Hospital Medicine

Rodriguez N, Kennedy AG, Tompkins BJ, VanOpdorp J, Heffley J, Ganguly E. Quality Improvement opportunities exist for helicobacter pylori treatment and confirmatory testing. Accepted to: Clinics and Research in Hepatology and Gastroenterology (4/24/21)

Division of Immunobiology

Montgomery TL, Paavola M, Bruce EA, Botten JW, Crothers JW, Krementsov DN. Laboratory worker self-contamination with non-infectious SARS-CoV-2 DNA can result in false positive RT-PCR-based surveillance testing. J Clin Microbiol. 2021 May 5:JCM.00723-21. doi: 10.1128/JCM.00723-21. Online ahead of print. PMID: 33952597

Drayman N, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Muñoz-Alía MÁ, Schuster B, Nair V, Botten JW, Brooke CB, Baker SC, Mounce BC, Heaton NS, Dickinson BC, Jaochimiak A, Randall G, Tay S. Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro. Science (in press)

Rissanen I, Krumm S, Stass R, Whitaker A, Voss JE, Bruce EA, Rothenberger S, Kunz S, Burton DR, Huiskonen JT, Botten JW, Bowden T, and Doores K. Structural basis for a neutralizing antibody response elicited by recombinant Hantaan virus Gn immunogen. mBio (in press)

Mills MG, Bruce E, Huang ML, Crothers JW, Hyrien O, Oura CAL, Blake L, Jordan AB, Hester S, Wehmas L, Mari B, Barby P, Lacoux C, Fassy J, Vial P, Vial C, Martinez JRW, Oladipo OO, Inuwa B, Shittu I, Meseko CA, Chammas R, Santos CF, Jose Dionisio T, Garbieri TF, Parisi VA, Mendes-Correa MC, dePaula AV, Romano CM, Goes LGB, Minoprio P, Campos AC, Cunha MP, Vilela APP, Nyirenda T, Mkakosya RS, Muula AS, Dumm RE, Harris RM, Mitchell CA, Pettit S, Botten J, Jerome KR. An international, interlaboratory ring trial confirms the feasibility of an open-source, extraction-less "direct" RT-qPCR method for reliable detection of SARS-CoV-2 RNA in clinical samples. medRxiv. 2021. Epub 2021/04/22. doi: 10.1101/2021.04.10.21254091. PubMed PMID: 33880478; PMCID: PMC8057246

Division of Infectious Disease

Lam BD, Hale A, Bullis SS, He YT, Khan S, Freed JA. A Retrospective Review of 193 Cases of Severe Eosinophilia in the Northeast United States. American Journal of Medicine, 2020;S0002-9343(20)31123-2. PMID 33359774. doi: 10.1016/j.amjmed.2020.11.022

Hale A. A Tale of Two Doctors. Journal of Medical Education and Training, 2021; 5:e055

Hale T, Petherick A, Phillips T, Sridhar S, Thompson R, Webster S, Hale A. Government responses and COVID-19 deaths: global evidence across multiple pandemic waves. Accepted at PLOS One May 30, 2021; in press

Ricotta D, Hale A, Freed J, Zeidel M, Herzig S. Generalists as Clinical Physiologists: Bringing science back to the bedside. Accepted Journal of General Internal Medicine on June 9, 2021; in press

Hasan MM, Stebbins E, Choy RKM, Gillespie JR, de Hostos EL, Miller P, Mushtaq A, Ranade RM, Teixeira JE, Verlinde CLMJ, Sateriale A, Zhang Z, Osbourn DM, Griggs DW, Fan E, Buckner F*, Huston CD*. Spontaneous selection of Cryptosporidium drug resistance in a calf model of infection. Antimicrobial Agents and Chemotherapy. 2021. Mar 22:AAC.00023-21. doi: 10.1128/AAC.00023-21. Online ahead of print. PMID: 33753338 *co-corresponding authors

Lahey T. How Should Clinicians Respond if Patient HIV Denial Could Exacerbate Racial Health Inequities? AMA Journal of Ethics 2021 May 1;23(5):E382-387. doi: 10.1001/amajethics.2021.382. https://edhub.ama-assn.org/ama-journal-of-ethics/module/2779244

Whitman TJ, Noyes CD, Hale AJ, Singh D, DeVoe SG, Repp AB, Pierce KK, Polish LB, Kirkpatrick BD, DeJace J, Smith LM, Lahey T, Huston CD, Catoe LJ, Ghatage P, Bullis S, Alson WK. The impact and costs of Hepatitis C virus screening programme for adults hospitalised at an academic medical centre. BMJ Open Qual 2021;10:e001248/doi: 10.1136/bmjoq-2020-001248

Smith LM and Ahern JW. (2021). Antimicrobial Stewardship During a Cyberattack. Infection Control and Hospital Epidemiology, 1-1. Doi:10.1017/ice.2021.235

Division of Pulmonary Disease and Critical Care Medicine

Dixon AE, Blake KV, DiMango EA, Dransfield MT, Feemster LC, Johnson O, Roy G, Hazucha H, Harvey J, McCormack MC, Wise RA & JT Holbrook. The challenge of addressing obesity in people with poorly controlled asthma. Obes Sci Pract. 2021. https://doi.org/10.1002/osp4.533

Roy GS, Daphtary N, Johnson O, Dixon AE, Kaminsky DA, Bates JHT. Measuring the mechanical input impedance of the respiratory system with breath-driven flow oscillations. J Appl Physiol (1985). 2021 Apr 1;130(4):1064-1071. doi: 10.1152/japplphysiol.00976.2020. Epub 2021 Feb 11. PMID: 33571055

Manuel AM, van de Wetering C, MacPherson M, Erickson C, Murray C, Aboushousha R, van der Velden J, Dixon AE, Poynter ME, Irvin CG, Taatjes DJ, van der Vliet A, Anathy V, Janssen-Heininger YMW. Dysregulation of pyruvate kinase M2 promotes inflammation in murine obese allergic asthma. American Journal of Respiratory Cell and Molecular Biology, doi: 10.1165/rcmb.2020-0512OC 2021). PMID 33662229

Ather JL, Van der Vliet K, Mank MM, Reed LF, Dixon AE, Poynter ME. Obese Adipose Tissue Modulates Pro-Inflammatory Responses of Mouse Airway Epithelial Cells. American Journal of Physiology – Regulatory, Integrative, and Comparative Biology, June 2, 2021. doi: 10.1152/ajpregu.00316.2020. PMID 43105399

Kokoszynska M, Ubags ND, Bivona III, JJ, Ventrone S, Reed LF, Dixon AE, Wargo MJ, Poynter ME, Suratt BT. Storage Conditions of High Fat Diets Affect Pulmonary Inflammation. In press, Physiological Reports, June 12, 2021

Uijtdehaage S, Ho MJ, Harvey E, Dorris CS, Huggett KN. Academies in Health Professions Education: A Scoping Review. Academic Medicine. 2021 May 11

Huggett KN, Jeffries WB. Overview of active learning research and rationale for active learning. In How-to Guide for Active Learning 2021 (pp. 1-7). Springer, Cham.

Jeffries WB, Huggett KN, Szarek J: Lectures. in Dent J. and Harden R.M., eds., A Practical Guide for Medical Teachers, 6th Edition, Edinburgh, Churchill Livingstone; 2021

Kaminsky DA, Grosset DG, Kegler-Ebo, DM, Cangiamilla S, Klingler M, Zhao P, Oh C. Natural history of lung function over one year in patients with Parkinson's Disease. Respir Med. 2021 Apr 16;182:106396. doi: 10.1016/j.rmed.2021.106396. Online ahead of print. PMID: 33866196

Saunders MJ, Haynes JM, McCormack MC, Stanojevic S, Kaminsky DA. How local SARS CoV-2 Prevalence Shapes Pulmonary Function Testing Laboratory Protocols and Practices During the COVID-19 Pandemic. Chest. May 2021 Online ahead of print. PMID: 34004155

Havercamp HC, Kaminsky DA, McPherson S, Irvin CG. Spirometric response to bronchodilator and eucapnic voluntary hyperpnea in non-asthmatic and asthmatic adults. Resp Care 2021. Online ahead of print. PMID: 34006592

Duchene G, Caffry S, Kaminsky DA, Que LG, Poynter ME, Dixon AE. Functional significance of 8-isoprostanes in sinonasal disease and asthma. Respir Med 2021. Online ahead of print. PMID: 34166960

Bivona II JJ, Crymble H, Guigni BA, Stapleton RD, Files DC, Toth MJ, Poynter ME, Suratt BT. Macrophages Augment the Muscle Inflammatory Response Through TNFα Following LPS-Induced Acute Lung Injury. FASEB Journal, 35(4):e21462 (2021). PMC7970444

Yan L, Song Y, Xia K, He P, Zhang F, Chen S, Pouliot R, Weiss DJ, Tandon R, Bates JT, Ederer DR, Mitra D, Sharma P, Davis A, Linhardt RJ. Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus. Carbohydrate Polymers, in press, 2021

Enes SR, Hampton TH, Barua J, McKenna DH, dos Santos CC, Amiel E, Asahre A, Liu KD, Krasnodembskaya AD, English K, Stanton BA, Rocco PRM, Matthay MA, Weiss DJ. Healthy versus Inflamed Lung Environments Differentially Effect MSCs. European Respiratory Journal. In press 2021

Lopes-Pacheco M, Carvalho L, Cruz FF, Khoury M, Weiss DJ, Rocco PRM. Mitochondria-rich Fraction Isolated from Mesenchymal Stromal Cells Reduce Lung and Distal Organ Injury. Experimental Sepsis Critical Care Medicine, in press 2021

Weiss DJ, Segal K, Casaburi R, Hayes J, Tashkin D. Effect of mesenchymal stromal cell infusions on lung function in COPD patients with high CRP levels. Respiratory Research, in press 2021

Dos Santos CC, Arnatullah H, Vaswani C, Kim M, Shan Y, Mei SHJ, Katalin S, Herrero R, Lorente JA, Esteban A, Marsden P, Hu P, Weiss DJ, Stewart DJ, Liles WC. Mesenchymal Stromal (stem) Cell (MSC) Therapy Modulates miR-193b-5p Expression to Attenuate Sepsis-Induced Acute Lung Injury. In press European Resp J, 2021

Antunes MA, Braga CL, De Oliviera TB, Kitoko JZ, De Castro LL, Xisto DG, Coleho MS, Rocha N, Martins EG, Galina A, Weiss DJ, Silva JRL, Lopes-Pacheco M, Cruz FF, Rocco PRM. Mesenchymal Stromal Cells from Emphysematous Donors and Their Extracellular Vesicles Are Unable to Reverse Cardiorespiratory Dysfunction in Experimental Severe Emphysema. In press Frontiers in Cell and Developmental Biology, section Stem Cell Research. 2021

Falcones B, Sanz H, Marhuenda E, Mendizabal I, Cabrera I, Malandain N, Uriarte JJ, Almendros I, Navajas, Weiss DJ, Farre R, Otero J. Bioprintable lung extracellular matrix hydrogel scaffolds for 3D culture of mesenchymal stromal cells. In press Polymers 2021

Abreu SC, Lopes-Pacheco M, Weiss DJ, Rocco PRM. Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Lung Diseases: Current Status and Perspectives. Frontiers Cell and Developmental Biology. In press 2021

Enes SR and Weiss DJ. Bioartificial lungs based on de- and recellularisation approaches: a historical perspective. European Respiratory Society Breathe 2020 16: 200168; DOI: 10.1183/20734735.0168-2020

Enes SR, Krasnodembskaya AD, English K, dos Santos CC, Weiss DJ. Research progress on strategies that can enhance the therapeutic benefits of MSCs in respiratory diseases. Frontiers in Pharmacology, section Respiratory Pharmacology. In press 2021

Wancyk H, Jensen T, Weiss DJ, Finck C. Advanced Single Cell Technologies to Guide the Development of Bioengineered Lungs. Am J Physiology. In press 2021

Viswanathan S, Ciccocioppo R, Galipeau J, Krampera M, LeBlanc K, Martin I, Moniz K, Nolta JA, Phinney DG, Shi Y, Szczepiorkowski ZM, Tarte, Weiss DJ, Ashford P. Consensus ICCBBA-ISCT statement on standard nomenclature abbreviations for the tissue of origin of Mesenchymal Stromal Cells. Cytotherapy, in press 2021

Samarelli AV,Tonelli R, Heijink I, Medina AM, Marchioni AM, Bruzzi G, Castaniere I, Andrisani D, Gozzi F, Manicardi L, Moretti A, Cerri A, FantiniR, Tabbì L, Nani CA, Mastrolia I, Weiss DJ, Dominici M, Clini E. Dissecting the role of mesenchymal stem cells in idiopathic pulmonary fibrosis: cause or solution? Frontiers in Pharmacology. In press 2021

Presentations
Division of Diabetes, Endocrinology and Metabolism

Shah A, Garapati S, Gilbert MP. A Rare Case of Actinomyces Infected Prolactinoma. AACE Virtual Annual Meeting. May 26-29, 2021

Abstract presented at the American Diabetes Association 81st Scientific Sessions: Gilbert MP, DeVoe SG, Kennedy AG, Ogelby M, Consigli AB, Zimakas PJ, Repp AB, Robinson KJ. Improving the quality of health care transitions for young adults at an adult endocrinology clinic [abstract]. Diabetes. 2021 Jun;70(suppl 1):852-P. doi: 10.2337/db21-852-P

Division of General Internal Medicine

Jessica Murphy, M.D., M.S., Paul O’Rourke, M.D., M.P.H., Erin Snyder, M.D. and Halle Sobel, M.D., presented a virtual workshop at the Academic Alliance for Internal Medicine Meeting titled “Seize the Moment: Using New ACGME Requirements as an Opportunity To Innovate Continuity Clinic Evaluations” at the Alliance for Academic Internal Medicine National Meeting in April of 2021