Welcome to the Cunniff Lab

Our research focuses on how mitochondrial dynamics and metabolic function dictate cell processes including cell migration and tumor cell metastasis. We utilize advanced microscopy approaches to visualize mitochondrial dynamics coupled with cellular biosensors and biochemical approaches to characterize metabolic features of distinct mitochondrial populations.

Additionally, we are developing novel therapies for the treatment of aggressive cancers such as malignant mesothelioma and ovarian cancer. We utilize cell and animal models to characterize metabolic features of tumor cells that provide susceptibility to compounds targeting mitochondrial function.

News & Announcements

Dynamic regulation of subcellular mitochondrial position for localized metabolite levels.

Alshaabi H, Heininger M, Cunniff B. J Biochem. 2019 Jul 29.

  • Cunniff Lab Highlighted in mSphere
    (JULY 2019) The Cunniff Lab research was recently the focus of a commentary in mSphere, a journal published by The American Society for Microbiology. This commentary highlighted the impact of our past and present research in field of sub cellular mitochondrial dynamics. Thank you Lena Pernas for highlighting our work!
Mitochondria in Neon Green

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