Welcome to the Cunniff Lab
Our research focuses on how mitochondrial dynamics and metabolic function dictate cell processes including cell migration and tumor cell metastasis. We utilize advanced microscopy approaches to visualize mitochondrial dynamics coupled with cellular biosensors and biochemical approaches to characterize metabolic features of distinct mitochondrial populations.
Additionally, we are developing novel therapies for the treatment of aggressive cancers such as malignant mesothelioma and ovarian cancer. We utilize cell and animal models to characterize metabolic features of tumor cells that provide susceptibility to compounds targeting mitochondrial function.