News

Of note:

News from Dr. Anathy’s lab

Please join Dr. Vikas Anathy in congratulating Nicolas Chamberlain and Dr. Emily Nakada.

Nicolas Chamberlain a PhD student recently published a paper entitled “Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics” in the journal Redox Biology (PMID 30735910). His abstract to be presented at the American Thoracic Society (ATS) conference was chosen to receive an abstract scholarship. The scholarship includes a full in-training registration to the 2019 ATS International Conference in Dallas, Texas. 

Dr. Emily Nakada was a post-doctoral fellow in our group. Her manuscript entitled “Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers” has been recently accepted in the journal JCI Insight.

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Please join Dr. Yvonne Janssen-Heininger in congratulating Allison Manuel and Evan Elko.

Dr. Allison Manuel is a post-doctoral fellow in our group.  Her abstract to be presented at the American Thoracic Society conference was chosen to receive an Abstract Scholarship . The scholarship includes a full In-Training Registration to the 2019 ATS International Conference in Dallas, Texas.  

Evan Elko is a PhD student. He just received notice that his F31 NIH application entitled: “Role of peroxiredoxin-4 in Idiopathic Pulmonary Fibrosis”  will be funded. 

Congratulations to Evan and Allison. 

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SRFBM conference 2018Christopher Dustin and Caspar Schiifers, students in Dr. Albert van der Vliet's lab, each won a Young Investigator Award for their presentations at the SRFBM conference in Chicago. (Nov 2018)

[photo left to right: students:C. Dustin, C. Schiffers, SRFBM president F. Domann, principal investigator A. van der Vliet]

Announcements

Dr. Jos van der Velden was featured in the 2019 summer edition of  Vermont Medicine.

Dr. Brian Cunniff's research was the focus of a recent commentary in mSphere, a journal published by The American Society for Microbiology. Congratulations Brian ! Read the commentary

Dr. Albert van der Vliet, Ph.D. has been asked to join the Editorial Board of Scientific Reports, an online open access journal from the publishers of Nature. Board members manage the peer review process for manuscripts submitted to the journal.

AlbertvanderVlietDr. Albert van der Vliet, Ph.D. will be a symposium speaker at an upcoming annual meeting of the Japanese Respiratory Society (April 12-14 in Tokyo), where he will be discussing the current status of oxidative stress in COPD and implications for therapeutic approaches.

Phil_MunsonPhillip Munson, a graduate student in Arti Shukla’s lab was recently invited to present his research to Dean Richard Page and the Medical Alumni Executive Committee. Thanks for representing UVM CMB graduate students!

Additionally, Phillip Munson will be presenting at the American Association for Cancer Research Meeting on April 1, 2019 in Atlanta Georgia. The title of his talk is “Exosomes in Mesothelioma. Congrats Phillip!

Janssen-HeiningerDr. Yvonne Jenssen-Heininger, Ph.D. will present a University Scholar Lecture: Using the Domain of Redox Biology to Understand Chronic Lung Diseases and to Provide Avenues for Drug Development, Wednesday, March 20th, 4:00 pm in the Waterman Memorial Lounge.

BrianCunniff

Dr. Brian Cunniff, Ph.D. received a UVM Cancer Center Pilot award entitled ”Mitochondrial positioning determines subcellular redox modifications supporting cell migration and metastasis.” Dr. Albert van der Vliet, Ph.D. will also serve as a Co-PI on the project. Congratulations to Drs. Cunniff and van der Vliet!

heintzDr. Nick Heintz, Ph.D. received the 2018 UVM Medical Alumni Association’s Distinguished Graduate Alumni Award​, which is presented to Larner College of Medicine (LCOM) alumni who have demonstrated outstanding achievement in basic, clinical or applied research; education; industry; public service/humanitarianism; and/or outstanding commitment to the LCOM community. He accepted his award at the college's Celebrating Research Excellence event at the end of October. (September 2018)

Janssen_Heininger_VCCDr. Yvonne Janssen-Heininger, Ph.D. to be inducted as a University Scholar...read here. (3/2018)

Dr. Yvonne Janssen-Heininger, Ph. D. was awarded a patent on the ​concept that strategies to inhibit GSTP has utility for the treatment of patients with pulmonary fibrosis. Congratulations, Yvonne! (Jan. 2018)

Publications

Little AC, Hristova M, van Lith L, Schiffers c, Dustin CM, Habibovic A, Danyal K, Heppner DE, Lin MJ, van der Velden J, Janssen-Heininger YM, van der Vliet A. "Dysregulated Redox Regulation Contributes to Nuclear EGFR Localization and Pathogenicity in Lung Cancer". Sci Rep. 2019 Mar 19;9(1):4844. doi: 10.1038/s41598-019-41395-8. PMID: 30890751

Heppner DE, Dustin CM, Liao C, Hristova M, Veith C, Little AC, Ahlers BA, White SL, Deng B, Lam YW, Li J, van der Vliet A. "Direct cysteine sulfenylation drives activation of the Src kinase". Nat Commun. 2018 Oct;9(1):4522. doi:10.1038/s41467-018-06790-1. PMID: 30375386 Free PMC Article

Anathy V, Lahue KG, Chapman DG, Chia SB, Casey DT, Aboushousha R, van der Velden JLJ, Elko E, Hoffman SM, McMillan DH, Jones JT, Nolin JD, Abdalla S, Schneider R, Seward DJ, Roberson EC, Liptak MD, Cousins ME, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, Ho YS, Hakem R, Brown KK, Matsui R, Bachschmid MM, Gomez JL, Kaminski N, van der Vliet A, Janssen-Heininger YMW. “Reducing protein oxidation reverses lung fibrosis.” Nat Med. 2018 Jul 9. doi: 10.1038/s41591-018-0090-y. [Epub ahead of print] PMID: 29988126

Bogdándi V, Ida T, Sutton TR, Bianco C, Ditrói T, Koster G, Henthorn HA, Minnion M, Toscano JP, van der Vliet A, Pluth MD, Feelisch M, Fukuto JM, Akaike T, Nagy P. “Speciation of Reactive Sulfur Species and their Reactions with Alkylating Agents: Do we have any clue about what is present inside the cell?” Br J Pharmacol. 2018 Jun 17. doi: 10.1111/bph.14394. [Epub ahead of print] PMID: 29909607 [PubMed - as supplied by publisher]

Vliet AV, Dick TP, Aust SD, Koppenol WH, Ursini F, Kettle AJ, Beckman JS, O'Donnell V, Darley-Usmar V, Lancaster J Jr, Hogg N, Davies KJA, Forman HJ, Janssen-Heininger YMW. “Rust never sleeps: The continuing story of the Iron Bolt.” Free Radic Biol Med. 2018 Jun 15. pii: S0891-5849(18)31063-3. doi: 10.1016/j.freeradbiomed.2018.06.017. [Epub ahead of print] Review. PMID: 29913216 [PubMed - as supplied by publisher]

Liu TL, Upadhyayula S, Milkie DE, Singh V, Wang K, Swinburne IA, Mosaliganti KR, Collins ZM, Hiscock TW, Shea J, Kohrman AQ, Medwig TN, Dambournet D, Forster R, Cunniff B, Ruan Y, Yashiro H, Scholpp S, Meyerowitz EM, Hockemeyer D, Drubin DG, Martin BL, Matus DQ, Koyama M, Megason SG, Kirchhausen T, Betzig E. “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms”. Science. 2018 Apr 20;360(6386). pii: eaaq1392. doi:10.1126/science.aaq1392. PMID: 29674564

Heppner DE, Hristova M, Ida T, Mijuskovic A, Dustin CM, Bogdándi V, Fukuto JM, Dick TP, Nagy P, Li J, Akaike T, van der Vliet A. “Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?” Redox Biol. 2018 Apr;14:379-385. doi: 10.1016/j.redox.2017.10.006. Epub 2017 Oct 9. PMID: 29054072 [PubMed - indexed for MEDLINE] Free PMC Article