News

Of note:

Congratulations to Dr. Arti Shukla, co-author on the manuscript "Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers" published in the journal Cell. Read the paper

Please join Dr. Yvonne Janssen-Heininger in congratulating Wyatt Chia on his successful thesis defense. Congratulations, Dr. Wyatt Chia, Ph.D.!!!

Please join Dr. Vikas Anathy in congratulating Nicolas Chamberlain and Dr. Emily Nakada.

Nicolas Chamberlain a PhD student recently published a paper entitled “Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics” in the journal Redox Biology (PMID 30735910). His abstract to be presented at the American Thoracic Society (ATS) conference was chosen to receive an abstract scholarship. The scholarship includes a full in-training registration to the 2019 ATS International Conference in Dallas, Texas. 

Dr. Emily Nakada was a post-doctoral fellow in our group. Her manuscript entitled “Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers” has been recently accepted in the journal JCI Insight.

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Please join Dr. Yvonne Janssen-Heininger in congratulating Allison Manuel and Evan Elko.

Dr. Allison Manuel is a post-doctoral fellow in our group.  Her abstract to be presented at the American Thoracic Society conference was chosen to receive an Abstract Scholarship . The scholarship includes a full In-Training Registration to the 2019 ATS International Conference in Dallas, Texas.  

Evan Elko is a PhD student. He just received notice that his F31 NIH application entitled: “Role of peroxiredoxin-4 in Idiopathic Pulmonary Fibrosis”  will be funded. 

Congratulations to Evan and Allison. 

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Christopher Dustin and Caspar Schiifers, students in Dr. Albert van der Vliet's lab, each won a Young Investigator Award for their presentations at the SRFBM conference in Chicago. (Nov 2018)

SRFBM conference 2018

[photo left to right: students:C. Dustin, C. Schiffers, SRFBM president F. Domann, principal investigator A. van der Vliet]


Announcements

Brian Cunniff, Ph.D., assistant professor of pathology and laboratory medicine and UVM Cancer Center member, was awarded a National Cancer Institute R03 grant, entitled “A pilot study to investigate in vivo Miro1 deletion in breast cancer tumorigenesis” (NIH award R03CA270840 ). This two-year, $156,000 grant will support Dr. Cunniff's investigation of the role of mitochondrial structure and function in the development and progression of breast cancer using a novel mouse model developed at Larner. Dr. Cunniff is a faculty member in the UVM Redox Biology and Pathology Program. (06/2022)

Dr. Elizabeth Corteselli, a post-doctoral fellow in our department and trainee on the VLC T32 training program, is the recipient of a prestigious Parker B. Francis Fellowship Award. She will be recognized during a reception at the ATS conference in San Francisco this coming week. Congratulations Elizabeth! (05/2022)

Yvonne Janssen-Heininger, Ph.D., professor of pathology and laboratory medicine has been recognized by the Provost and Senior Vice-President for the university of Vermont Distinguished Professor recognition. This recognition is reserved for the most prominent faculty members who have made outstanding contributions to advancing knowledge in their disciplines. This is a significant honor for Dr. Janssen-Heininger. This accolade will be awarded during the spring 2022 UVM Commencement ceremony. Congratulations!! (05/2022)

Yvonne Janssen-Heininger, Ph.D., professor of pathology and laboratory medicine has been awarded a UVM Cancer Center Pilot Project grant for the project titled “Glutaredoxin, glutathione metabolism and lung cancer,” Dr. Janssen-Heininger’s project is a collaborative undertaking with C. Matthew Kinsey, M.D., M.P.H., associate professor of medicine, and Adrianus “Jos” Van der Velden, Ph.D., associate professor of pathology and laboratory medicine, targeting glutathione levels in cancer organoids.

Congratulations! Dr. Yvonne Janssen-Heininger, Ph.D. – Dean’s Research Laureate Award (Professor)
Dr. Yvonne Janssen-Heininger was presented the Dean’s Research Laureate Award on 10/27/2021 at the LCOM State of
Research Address and Awards. Please see the PDF slide that was presented at the program. (10/2021)

Heading to clinical trials..."UVM researchers celebrate ‘first-of-its-kind’ mesothelioma treatment headed to clinical trials" – My Champlain Valley News.  University of Vermont researchers have made a breakthrough in their study of possible
treatments for malignant mesothelioma, a rare and aggressive cancer linked to asbestos exposure. (10/2021)

Congratulations! Albert van der Vliet, Ph.D. has been named a 2021 Fellow of the Society for Redox Biology and Medicine. SfRBM annually confers the special title of Fellow to members who have made outstanding contributions to the association as well as in the field of free radical chemistry, redox biology and antioxidants. (09/2021)

Congratulations to Dr. Yvonne Janssen-Heininger, Dr. Albert van der Vliet, Dr. David Seward and their team members for this outstanding acknowledgement (see pdf) from the The American Physiological Society; "your article has been selected for APSselect  (http://apsselect.physiology.org/),  a collection from the APS that showcases some of the best recently published articles in physiological research." (7/2021)

Congratulations to Dr. Arti Shukla on receiving the SAASCR 2021 Outstanding Achievement Award for her seminal contributions to the field of cancer research. Well done Arti!! (5/2021)

SAASCR award 2021

Publications

Nicolas Chamberlain, Ph.D., formerly of the Anathy Lab, recently published "Protein Disulfide Isomerase A3 Regulates Influenza Neuraminidase Activity and Influenza Burden in the Lung." Chamberlain, N.; Ruban, M.; Mark, Z.F.; Bruno, S.R.; Kumar, A.; Chandrasekaran, R.; Souza De Lima, D.; Antos, D.; Nakada, E.M.; Alcorn, J.F.; Anathy, V.  Int. J. Mol. Sci. 2022, 23, 1078.

Vikas Anathy, Ph. D., et.al. recently published a paper that reports a new relationship between PDIA3, club cells, and a pro-fibrotic growth factor osteopontin in lung fibrosis. "Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis." Kumar A, Elko E, Bruno SR, Mark ZF, Chamberlain N, Mihavics BK, Chandrasekaran R, Walzer J, Ruban M, Gold C, Lam YW, Ghandikota S, Jegga AG, Gomez JL, Janssen-Heininger YM, Anathy V. Thorax. 2021 Aug 16:thoraxjnl-2021-216882. doi: 10.1136/thoraxjnl-2021-216882. Online ahead of print. PMID: 34400514   https://thorax.bmj.com/content/early/2021/08/16/thoraxjnl-2021-216882

Alshaabi H, Shannon N, Gravelle R, Milczarek S, Messier T, Cunniff B. “Miro1-mediated mitochondrial positioning supports subcellular redox status.” Redox Biology 2020

Munson, Phillip B., Hall, Elizabeth M., Farina, Nicholas H., Pass, Harvey I., Shukla, Arti. "Exosomal miR-16-5p as a target for malignant mesothelioma." 2019 Sci Rep. Aug 19;9(1):11688 doi: 10.1038/s41598-019-48133-0

Alshaabi H, Heininger M, Cunniff B. “Dynamic regulation of subcellular mitochondrial position for localized metabolite levels.” J Biochem. 2019 Jul 29. pii: mvz058. doi: 10.1093/jb/mvz058. [Epub ahead of print] PubMed PMID: 31359061.

Little AC, Hristova M, van Lith L, Schiffers c, Dustin CM, Habibovic A, Danyal K, Heppner DE, Lin MJ, van der Velden J, Janssen-Heininger YM, van der Vliet A. "Dysregulated Redox Regulation Contributes to Nuclear EGFR Localization and Pathogenicity in Lung Cancer". Sci Rep. 2019 Mar 19;9(1):4844. doi: 10.1038/s41598-019-41395-8. PMID: 30890751

Heppner DE, Dustin CM, Liao C, Hristova M, Veith C, Little AC, Ahlers BA, White SL, Deng B, Lam YW, Li J, van der Vliet A. "Direct cysteine sulfenylation drives activation of the Src kinase". Nat Commun. 2018 Oct;9(1):4522. doi:10.1038/s41467-018-06790-1. PMID: 30375386 Free PMC Article

Anathy V, Lahue KG, Chapman DG, Chia SB, Casey DT, Aboushousha R, van der Velden JLJ, Elko E, Hoffman SM, McMillan DH, Jones JT, Nolin JD, Abdalla S, Schneider R, Seward DJ, Roberson EC, Liptak MD, Cousins ME, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, Ho YS, Hakem R, Brown KK, Matsui R, Bachschmid MM, Gomez JL, Kaminski N, van der Vliet A, Janssen-Heininger YMW. “Reducing protein oxidation reverses lung fibrosis.” Nat Med. 2018 Jul 9. doi: 10.1038/s41591-018-0090-y. [Epub ahead of print] PMID: 29988126

Bogdándi V, Ida T, Sutton TR, Bianco C, Ditrói T, Koster G, Henthorn HA, Minnion M, Toscano JP, van der Vliet A, Pluth MD, Feelisch M, Fukuto JM, Akaike T, Nagy P. “Speciation of Reactive Sulfur Species and their Reactions with Alkylating Agents: Do we have any clue about what is present inside the cell?” Br J Pharmacol. 2018 Jun 17. doi: 10.1111/bph.14394. [Epub ahead of print] PMID: 29909607 [PubMed - as supplied by publisher]

Vliet AV, Dick TP, Aust SD, Koppenol WH, Ursini F, Kettle AJ, Beckman JS, O'Donnell V, Darley-Usmar V, Lancaster J Jr, Hogg N, Davies KJA, Forman HJ, Janssen-Heininger YMW. “Rust never sleeps: The continuing story of the Iron Bolt.” Free Radic Biol Med. 2018 Jun 15. pii: S0891-5849(18)31063-3. doi: 10.1016/j.freeradbiomed.2018.06.017. [Epub ahead of print] Review. PMID: 29913216 [PubMed - as supplied by publisher]

Liu TL, Upadhyayula S, Milkie DE, Singh V, Wang K, Swinburne IA, Mosaliganti KR, Collins ZM, Hiscock TW, Shea J, Kohrman AQ, Medwig TN, Dambournet D, Forster R, Cunniff B, Ruan Y, Yashiro H, Scholpp S, Meyerowitz EM, Hockemeyer D, Drubin DG, Martin BL, Matus DQ, Koyama M, Megason SG, Kirchhausen T, Betzig E. “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms”. Science. 2018 Apr 20;360(6386). pii: eaaq1392. doi:10.1126/science.aaq1392. PMID: 29674564

Heppner DE, Hristova M, Ida T, Mijuskovic A, Dustin CM, Bogdándi V, Fukuto JM, Dick TP, Nagy P, Li J, Akaike T, van der Vliet A. “Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?” Redox Biol. 2018 Apr;14:379-385. doi: 10.1016/j.redox.2017.10.006. Epub 2017 Oct 9. PMID: 29054072 [PubMed - indexed for MEDLINE] Free PMC Article