News

Of note:

Agilent Lab Visit 01.25.2023 editsThe RBP group took a tour of the new Agilent Laboratory for Chemical Analysis in Discovery Hall. "This new lab is a state-of-the-art instrumentation facility available to the UVM and business communities." (2023)

Congratulations to Dr. Arti Shukla, co-author on the manuscript "Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers" published in the journal Cell. Read the paper

Please join Dr. Yvonne Janssen-Heininger in congratulating Wyatt Chia on his successful thesis defense. Congratulations, Dr. Wyatt Chia, Ph.D.!!!

Please join Dr. Vikas Anathy in congratulating Nicolas Chamberlain and Dr. Emily Nakada.

Nicolas Chamberlain a PhD student recently published a paper entitled “Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics” in the journal Redox Biology (PMID 30735910). His abstract to be presented at the American Thoracic Society (ATS) conference was chosen to receive an abstract scholarship. The scholarship includes a full in-training registration to the 2019 ATS International Conference in Dallas, Texas. 

Dr. Emily Nakada was a post-doctoral fellow in our group. Her manuscript entitled “Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers” has been recently accepted in the journal JCI Insight.

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Please join Dr. Yvonne Janssen-Heininger in congratulating Allison Manuel and Evan Elko.

Dr. Allison Manuel is a post-doctoral fellow in our group.  Her abstract to be presented at the American Thoracic Society conference was chosen to receive an Abstract Scholarship . The scholarship includes a full In-Training Registration to the 2019 ATS International Conference in Dallas, Texas.   

Evan Elko is a PhD student. He just received notice that his F31 NIH application entitled: “Role of peroxiredoxin-4 in Idiopathic Pulmonary Fibrosis”  will be funded.  

Congratulations to Evan and Allison. 

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Christopher Dustin and Caspar Schiifers, students in Dr. Albert van der Vliet's lab, each won a Young Investigator Award for their presentations at the SRFBM conference in Chicago. (Nov 2018)

SRFBM conference 2018

[photo left to right: students:C. Dustin, C. Schiffers, SRFBM president F. Domann, principal investigator A. van der Vliet]


Announcements

vandervliet-habibovic420x280A new study by Albert van der Vliet, Ph.D., professor of pathology and laboratory medicine, and a team of University of Vermont (UVM) researchers is honing in on why people with asthma often have worse symptoms if they are obese. This new research demonstrates that the gene DUOX1 likely contributes to the connection between obesity and asthma.  The research was published ahead of print in the American Journal of Physiology-Lung Cellular and Molecular Physiology and was highlighted as an APSselect article for March 2023. Albert van der Vliet, Ph.D., was the senior author on the paper, along with department of pathology and laboratory medicine coauthors Aida Habibovic, lab research technician;Litiele Cruz, Ph.D., visiting scholar; Vikas Anathy, Ph.D., associate professor; University Distinguished Professor Yvonne Janssen-Heininger, Ph.D.; and additional team members and authors from UVM. Read the full LCOM News story LCOM News (4/2023)

Congratulations to the following recipients that received pathology research support funding. Nathaniel Shannon in Brian Cunniff's, Ph.D., lab was awarded $1800 towards the cost of travel to the 2022 Annual Meeting of the Society for Redox Biology and Medicine (SfRBM). Litiele Cruz, Ph.D., and faculty mentor Albert van der Vliet, PhD., were awarded $2622 for her project "Characterization of Laminin Oxidative Modifications by Peroxidasin in Pulmonary Fibrosis"Nels Olson, PhD., MPH., $14,582 for the purchase of an Agilent BioTek 405 TS Touch Microplate Washer, Model 405 TSRS. Ashley Volaric M.D., Joanna Conant M.D., and David Seward, M.D, Ph.D., were awarded $13,680 for their project, "The Effect of Epstein Barr Virus Latency on Cellular DNA Methylation Profile of Diffuse Large B Cell Lymphoma". (3/2023)

Albert in JapanCongratulations to Dr. Albert van der Vliet, Ph.D., professor of pathology and laboratory medicine, for being selected as an Invited Fellow to Tohoku University in Sendai, Japan, to participate in research in the laboratory of Takaaki Akaike, M.D., Ph.D., professor of environmental medicine and molecular toxicology. The invitational fellowship relates to a Tohoku University initiative that allows Tohoku faculty members to host invited researchers to promote collaborative research in the host lab for up to three months. The objective is to promote joint publications and expand international collaborations. Dr. van der Vliet's visit coincided with a medley of scientific meetings and symposia collectively termed  Redox Week In Sendai 2022 and held October 27-November 1, 2022. The events brought together leading scientists from around the world in the specific research fields of nitric oxide biology, polysulfur biochemistry, and biology. Van der Vliet was co-organizer and speaker at one of the symposiums, and Yvonne Janssen-Heininger, Ph.D., and Brian Cunniff, Ph.D., both professors of pathology and laboratory medicine, also participated as invited speakers. Additional Japanese federal funding supports the exchange of invited researchers, graduate students, and post-doctoral scholars to collaborate on research. Read more about the redox research collaboration  between UVM and Tohoku University. (01/2023)

Congratulations, to Dr. Yvonne Janssen-Heininger, Ph.D., on her Lung Cancer Discovery Award from the American Lung Association. Read the full article here: VermontBiz (10/2022)

Litele Cezar de Cruz, Ph.D., a visiting scholar from Brazil in the lab of Dr. Albert van der Vliet, Ph.D., and Nathaniel Shannon, a graduate student in the CMB program, in the lab of Dr. Brian Cunniff, Ph.D., based on their abstracts, have both received a Travel Award from SfRBM to attend the SfRBM Annual Meeting in Orlando later this year. https://sfrbm.org/meetings/2022-annual-conference/. In addition, Nate's abstract was selected to be presented as a talk at the conference. Chris Dustin, a former RBP Ph.D. student, and now a post-doc candidate at University of Pittsburg will also give an oral presentation at the conference. RBP is again well represented at this major conference in our field. (10/2022)

Brian Cunniff, Ph.D., assistant professor of pathology and laboratory medicine and UVM Cancer Center member, was awarded a National Cancer Institute R03 grant, entitled “A pilot study to investigate in vivo Miro1 deletion in breast cancer tumorigenesis” (NIH award R03CA270840 ). This two-year, $156,000 grant will support Dr. Cunniff's investigation of the role of mitochondrial structure and function in the development and progression of breast cancer using a novel mouse model developed at Larner. Dr. Cunniff is a faculty member in the UVM Redox Biology and Pathology Program. (06/2022)

Dr. Elizabeth Corteselli, a post-doctoral fellow in our department and trainee on the VLC T32 training program, is the recipient of a prestigious Parker B. Francis Fellowship Award. She will be recognized during a reception at the ATS conference in San Francisco this coming week. Congratulations Elizabeth! (05/2022)

Yvonne Janssen-Heininger, Ph.D., professor of pathology and laboratory medicine has been recognized by the Provost and Senior Vice-President for the university of Vermont Distinguished Professor recognition. This recognition is reserved for the most prominent faculty members who have made outstanding contributions to advancing knowledge in their disciplines. This is a significant honor for Dr. Janssen-Heininger. This accolade will be awarded during the spring 2022 UVM Commencement ceremony. Congratulations!! (05/2022)

Yvonne Janssen-Heininger, Ph.D., professor of pathology and laboratory medicine has been awarded a UVM Cancer Center Pilot Project grant for the project titled “Glutaredoxin, glutathione metabolism and lung cancer,” Dr. Janssen-Heininger’s project is a collaborative undertaking with C. Matthew Kinsey, M.D., M.P.H., associate professor of medicine, and Adrianus “Jos” Van der Velden, Ph.D., associate professor of pathology and laboratory medicine, targeting glutathione levels in cancer organoids.

Congratulations! Dr. Yvonne Janssen-Heininger, Ph.D. – Dean’s Research Laureate Award (Professor)
Dr. Yvonne Janssen-Heininger was presented the Dean’s Research Laureate Award on 10/27/2021 at the LCOM State of
Research Address and Awards. Please see the PDF slide that was presented at the program. (10/2021)

 

"Diagnosing calciphylaxis: A series of cases with both imaging and tissue biopsy." Alniemi DT, Kanner C, Stowman AM, Knapp M, McGevna L, Seward DJ, Bui MR. Journal of the American Academy of Dermatology. 2023 May;88(5):1117-1119. doi: 10.1016/j.jaad.2020.05.111. Epub 2020 Jun 8. PMID: 32526323

Corrigendum to "Spatiotemporal higher-order chromatin landscape of human histone gene clusters at Histone Locus Bodies during the cell cycle in breast cancer progression." Ghule PN, Boyd JR, Kabala F, Fritz AJ, Bouffard NA, Gao C, Bright K, Macfarlane J, Seward DJ, Pegraro G, Misteli T, Lian JB, Frietze S, Stein JL, van Wijnen AJ, & Stein GS. [Gene 872 (2023)147441]. Gene 873, 147469 Advance online publication. https://doi.org/10.1016/j.gene.2023.147469

"Spatiotemporal higher-order chromatin landscape of human histone gene clusters at Histone Locus Bodies during the cell cycle in breast cancer progression." Ghule PN, Boyd JR, Kabala F, Fritz AJ, Bouffard NA, Gao C, Bright K, Macfarlane J, Seward DJ, Pegraro G, Misteli T, Lian JB, Frietze S, Stein JL, van Wijnen AJ, & Stein GS. Gene,147441. 2023 Advance online publication. https://doi.org/10.1016/j.gene.2023.147441

"Addressing the Environmental Impact of Science Through a More Rigorous, Reproducible, and Sustainable Conduct of Research." Meyn SM, Ramirez-Aguilar KA, Gregory CW, Mische S, Ott AW, Sol-Church K, Sturges M, Taatjes DJ. Journal of Biomolecular Techniques. 2023 Feb 28;33(4):3fc1f5fe.d085ce95. doi: 10.7171/3fc1f5fe.d085ce95. PMID: 37033093; PMCID:10078834

"Rigor, Reproducibility, and Transparency in Shared Research Resources: Follow-up Survey and Recommendations for Improvement." Journal of Biomolecular Techniques. Ott AW, Sol-Church K, Deshpande GM, Knudtson KL, Meyn SM, Mische SM, Taatjes DJ, Sturges MR, Gregory CW. 2022 Aug 16;33(3):3fc1f5fe.fa789303. doi: 10.7171/3fc1f5fe/fa789303. PMID: 36910580; PMCID: PMC10001929

"Novel post-acquisition image processing to attenuate red blood cell autofluorescence for quantitative image analysis." Epub ahead of print. Bouffard NA, Lee K, DeLance NM, Clason T, Chatterjee N, Taatjes DJ. 2022 Oct 19. doi: 10.1007/s00418-022-02159-0. PMID: 36260111

"Differences in Treatment Response in Bronchial Epithelial Cells from Idiopathic Pulmonary Fibrosis (IPF) Patients: A First Step towards Personalized Medicine?." Antioxidants (Basel). Veith C, Schneider MA, Maas L, van der Vliet A, van Schooten FJ, Kreuter M, Meister M, Boots AW, Kahn N. 2023 Feb 10;12(2):443. doi: 10.3390/antiox12020443. PMID: 36830000; PMCID: PMC9952618

"Diet-Induced Obesity Worsens Allergen-Induced Type 2/Type 17 Inflammation Ain Airways by Enhancing DUOX1 Activation." Habibovic A, Hristova M, Morris CR, Lin MJ, Cruz LC, Ather JL, Geizst M, Anathy, V, Janssen-Heininger YMW, Poynter ME, Dixon AE, van der Vliet A. 2023 Jan 10. doi: 10.1152/ajplung.00331.2022. Epub ahead of print. PMID: 36625485

"In Focus in HCB." Taatjes DJ, Roth J. Histochemistry Cell Biology. 2023 Jan 9:1-3. doi: 10.1007/s00418-022-02176-z. Epub ahead of print. PMID: 36622387; PMCID: PMC9827435

"Mitoquinone mesylate attenuates pathologic features of lean and obese allergic asthma in mice." Chandrasekaran RBruno SRMark ZF, Walzer J, Caffry S, Gold C, Kumar A, Chamberlain N, Butzirus IM, Morris CR, Daphtary N, Aliyeva M, Lam YM, van der Vliet AJanssen-Heininger Y, Poynter ME, Dixon AE, Anathy V. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2022 Dec 13. doi: 10.1152/ajplung.00249.2022. Epub ahead of print. PMID: 365151

A recent editorial from Vikas Anathy. Editorial: "Oxidative stress related to cellular metabolism in lung health and diseases." Arunachalam K, Anand K, Palanisamy S, Anathy V. Frontiers in Pharmacology 2022 Nov 3;13:1015423. doi: 10.3389/fphar.2022.1015423. PMID: 36408268; PMCID: PMC9670798

A recent publication from Yvonne Janssen-Heininger's lab. "S Glutathionylation-Controlled Apoptosis of Lung Epithelial Cells; Potential Implications for Lung Fibrosis." Corteselli EAboushousha RJanssen-Heininger YM, Antioxidants (Basel) 2022 Sep 10;11(9):1789. doi: 10.3390/antiox11091789. PMID 3619863

A recent publication from Vikas Anathy. "Inhibition of PDIA3 in club cells attenuates steopontin production and lung fibrosis." Kumar A, Elko E, Bruno, S.R., Mark ZF, Chamberlain N, Mihavics BK, Chandrasekaran R, Walzer J, Ruban M, Gold C, Lam YW, Ghandikota S, Jegga AG, Gomez JL, Janssen-Heininger YMAnathy, V. Thorax 2022 Jul;77(7):669-678. doi: 10.1136/thoraxjnl-2021-216882. Epub 2021 Aug 16. PMID 34400514

Nicolas Chamberlain, Ph.D., formerly of the Anathy Lab, recently published "Protein Disulfide Isomerase A3 Regulates Influenza Neuraminidase Activity and Influenza Burden in the Lung." Chamberlain, N.; Ruban, M.; Mark, Z.F.; Bruno, S.R.; Kumar, A.; Chandrasekaran, R.; Souza De Lima, D.; Antos, D.; Nakada, E.M.; Alcorn, J.F.Anathy, V.  Int. J. Mol. Sci. 2022, 23, 1078.

Vikas Anathy, Ph. D., et.al. recently published a paper that reports a new relationship between PDIA3, club cells, and a pro-fibrotic growth factor osteopontin in lung fibrosis. "Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis." Kumar A, Elko E, Bruno SR, Mark ZF, Chamberlain N, Mihavics BK, Chandrasekaran R, Walzer J, Ruban M, Gold C, Lam YW, Ghandikota S, Jegga AG, Gomez JL, Janssen-Heininger YM, Anathy V. Thorax. 2021 Aug 16:thoraxjnl-2021-216882. doi: 10.1136/thoraxjnl-2021-216882. Online ahead of print. PMID: 34400514   https://thorax.bmj.com/content/early/2021/08/16/thoraxjnl-2021-216882

Alshaabi H, Shannon N, Gravelle R, Milczarek S, Messier T, Cunniff B. “Miro1-mediated mitochondrial positioning supports subcellular redox status.” Redox Biology 2020

Munson, Phillip B., Hall, Elizabeth M., Farina, Nicholas H., Pass, Harvey I., Shukla, Arti. "Exosomal miR-16-5p as a target for malignant mesothelioma." 2019 Sci Rep. Aug 19;9(1):11688 doi: 10.1038/s41598-019-48133-0

Alshaabi H, Heininger M, Cunniff B. “Dynamic regulation of subcellular mitochondrial position for localized metabolite levels.” J Biochem. 2019 Jul 29. pii: mvz058. doi: 10.1093/jb/mvz058. [Epub ahead of print] PubMed PMID: 31359061.

Little AC, Hristova M, van Lith L, Schiffers c, Dustin CM, Habibovic A, Danyal K, Heppner DE, Lin MJ, van der Velden J, Janssen-Heininger YM, van der Vliet A. "Dysregulated Redox Regulation Contributes to Nuclear EGFR Localization and Pathogenicity in Lung Cancer". Sci Rep. 2019 Mar 19;9(1):4844. doi: 10.1038/s41598-019-41395-8. PMID: 30890751

Heppner DE, Dustin CM, Liao C, Hristova M, Veith C, Little AC, Ahlers BA, White SL, Deng B, Lam YW, Li J, van der Vliet A. "Direct cysteine sulfenylation drives activation of the Src kinase". Nat Commun. 2018 Oct;9(1):4522. doi:10.1038/s41467-018-06790-1. PMID: 30375386 Free PMC Article